API-Sparing Techniques to Determine Drug Absorption Potential
Ionization and Log P- Gemini Profiler™ provides pKa and lipophilicity with sub-milligram samples using
semi-automated acid base titrations.
Permeability- PAMPA artificial membrane measurements are highly correlated with GI, BBB and CaCO2 permeability. Available in turnkey manual and robotic platforms in 96 well plates; includes technical support.
Dissolution and Solubility- µDISS Profiler™ provides real time UV based concentration data simultaneously in 6-8
tests using milligrams API and 1 mL media. Great to detect polymorphic changes, salt selection and metastable
solubility states.
Solubility- Accurate, high throughput screening using both manual or automated liquid handling systems. The
patented method features software which detects impurities or decomposition in the UV spectra.
Ionization and Log P- Gemini Profiler™ provides pKa and lipophilicity with sub-milligram samples using
semi-automated acid base titrations.
Permeability- PAMPA artificial membrane measurements are highly correlated with GI, BBB and CaCO2 permeability. Available in turnkey manual and robotic platforms in 96 well plates; includes technical support.
Dissolution and Solubility- µDISS Profiler™ provides real time UV based concentration data simultaneously in 6-8
tests using milligrams API and 1 mL media. Great to detect polymorphic changes, salt selection and metastable
solubility states.
Solubility- Accurate, high throughput screening using both manual or automated liquid handling systems. The
patented method features software which detects impurities or decomposition in the UV spectra.
